T cell infiltration into the brain triggers pulmonary dysfunction in murine Cryptococcus-associated IRIS

T cell infiltration into the brain triggers pulmonary dysfunction in murine Cryptococcus-associated IRIS

Blog Article

Abstract Cryptococcus-associated immune reconstitution inflammatory syndrome (C-IRIS) PRO MG 12 MIXED BERRY is a condition frequently occurring in immunocompromised patients receiving antiretroviral therapy.C-IRIS patients exhibit many critical symptoms, including pulmonary distress, potentially complicating the progression and recovery from this condition.Here, utilizing our previously established mouse model of unmasking C-IRIS (CnH99 preinfection and adoptive transfer of CD4+ T cells), we demonstrated that pulmonary dysfunction associated with the C-IRIS condition in mice could be attributed to the infiltration of CD4+ T cells into the brain via the CCL8-CCR5 axis, which triggers the nucleus tractus solitarius (NTS) neuronal damage and neuronal disconnection via upregulated ephrin B3 and semaphorin 6B in CD4+ T cells.Our findings provide unique insight into the mechanism behind pulmonary dysfunction in C-IRIS and nominate Utensils potential therapeutic targets for treatment.